GenieTAGTM, the company’s first commercially available, patent pending product is a small molecular weight site-specific (~200 Da), highly hydrophilic “linker”. It allows introduction of a single azide functional group to the protein of interest in a simple, quick and non-enzymatic way. This all comes with the added benefit of allowing the end-user to (optionally) remove the installed linker via a controlled reversible reaction, leaving the native protein untouched.
After GenieTAGTM has been installed on a protein of interest, the azide-functional group opens the door to a plethora of different payloads that can be conjugated via Click Chemistry – a technique that was recently awarded the Nobel Prize in 2022.
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KEY BENEFITS
Small chemical linker
Exclusively labels N-termini of proteins
Compatible with most common N-terminal sequences
Very mild reaction conditions (pH 7)
Rapid (1-3h)
Achieves near complete conversion with negligible off-site labelling