Most non-specific chemistries involve reactions between primary amines and NHS esters or sulfhydryls and maleimides. We apply these non-specific reactions to scaffolds, Virus-like-particles (VLPs), lipid nanoparticles (LNPs) and exosomes, decorating their surface for subsequent attachment of a desired payload.
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GenieTAGTM is a small molecular weight site-specific (~200 Da), highly hydrophilic linker. It allows introduction of a single azide functional group to the protein of interest in a simple, quick and non-enzymatic way.
After GenieTAGTM has been installed on a protein of interest, the azide-functional group opens the door to a plethora of different payloads that can be conjugated via Click Chemistry